ZIA BC 010997 (ZIA) | |||
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Title | Purification of a Novel Antibody Against Solid Organ Cancer Stem Cells | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Avital, Itzhak | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $85,103 | Project Dates | 10/01/2007 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Cancer Survivorship (10.0%) Childhood Cancers (20.0%) Digestive Diseases (90.0%) Organ Transplantation Research (100.0%) Surgery (100.0%) |
Anus (10.0%) Breast (2.0%) Colon/Rectum (10.0%) Liver Cancer (30.0%) Melanoma (5.0%) Pancreas (30.0%) Sarcoma (3.0%) Stomach (10.0%) |
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Research Type | |||
Cancer Progression and Metastasis Systemic Therapies - Discovery and Development |
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Abstract | |||
We are purifying populations of putative cancer stem cells from hepatocellular carcinoma, cholangiocarcinoma, pancreatic adenocarcinoma, melanoma and gastric cancer using a novel functional approach. We preliminarrily were able to generate a polyclonal antibody spesific for cancer stem cells. Now we are in the proccess of generating a monoclonal antibody. Subsequently, we will purify the specific protein and will test the antibody against a variety of various cancers. We hope to study the predictive value of this antibody as an early predictor. |